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Histone Deacetylase Inhibitors Induce the Differentiation of Eosinophilic Leukemia EoL-1 Cells into Eosinophils

Authors
Kenji ISHIHARAJangJa HONGMotoko KANEKOAki TAKAHASHIHiroki SUGENO강영숙Kazuo OHUCHI
Issue Date
Jun-2006
Publisher
한국응용약물학회
Citation
The Journal of Applied Pharmacology, v.14, no.2, pp 67 - 74
Pages
8
Journal Title
The Journal of Applied Pharmacology
Volume
14
Number
2
Start Page
67
End Page
74
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15218
ISSN
1976-9148
2005-4483
Abstract
EoL-1 cels diferentiate into eosinophils in the presence of n-butyrate, but the mechanism hasremained to be elucidated. Because n-butyrate can inhibit histone deacetylases, we hypothesized that the inhibi-tion of histone deacetylases induces the diferentiation of EoL-1 cells into eosinophils. In this study, using n-ship between the inhibition of histone deacetylases and the diferentiation into eosinophils in EoL-1 cells. It wasdemonstrated that apicidin and n-butyrate induced a continuous acetylation of histones H4 and H3, inhibited theproliferation of EoL-1 cels, and induced the expression of markers for mature eosinophils such as integrin β7,CCR1, and CCR3 on EoL-1 cels, while trichostatin A evoked a transient acetylation of histones and induced noEoL-1 cells induces the diferentiation into mature eosinophils.Keywords . EoL-1 cells, eosinophils, differentiation, histone deacetylase inhibitor
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