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A novel telomerase-derived peptide GV1001-mediated inhibition of angiogenesis: Regulation of VEGF/VEGFR-2 signaling pathwaysopen access

Authors
Kim, Jae HyeonCho, Young-RakAhn, Eun-KyungKim, SunhoHan, SurimKim, Sung JoonBae, Gyu-UnOh, Joa SubSeo, Dong-Wan
Issue Date
Dec-2022
Publisher
Neoplasia Press, Inc.
Keywords
Angiogenesis; GV1001; Non-small cell lung cancer; Telomerase-derived peptide; VEGF
Citation
Translational Oncology, v.26, pp 1 - 11
Pages
11
Journal Title
Translational Oncology
Volume
26
Start Page
1
End Page
11
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/152274
DOI
10.1016/j.tranon.2022.101546
ISSN
1936-5233
Abstract
GV1001, a human telomerase reverse transcriptase catalytic subunit-derived 16-mer peptide, has been developed as a novel anticancer vaccine against various cancers including pancreatic cancer. In the current study, we demonstrate the regulatory roles and mechanisms of GV1001 in endothelial cell responses in vitro and microvessel sprouting ex vivo. GV1001 markedly inhibits vascular endothelial growth factor-A (VEGF-A)-stimulated endothelial cell permeability, proliferation, migration, invasion, tube formation as well as microvessel outgrowth from rat aortic rings. These anti-angiogenic effects of GV1001 were associated with the inhibition of VEGF-A/VEGFR-2 signaling pathways, redistribution of vascular endothelial-cadherin to cell–cell contacts, and down-regulation of VEGFR-2 and matrix metalloproteinase-2. Furthermore, GV1001 suppresses the proliferation and invasion of non-small cell lung cancer cells, and the release of VEGF from the cells, suggesting the regulatory role of GV1001 in tumor-derived angiogenesis as well as cancer cell growth and progression. Collectively, our study reports the pharmacological potential of GV1001 in the regulation of angiogenesis, and warrants further evaluation and development of GV1001 as a promising therapeutic agent for a variety of angiogenesis-related diseases including cancer. © 2022
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