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Blood-Brain Barrier Solute Carrier Transporters and Motor Neuron Diseaseopen access

Authors
Latif, SanaKang, Young-Sook
Issue Date
Oct-2022
Publisher
MDPI
Keywords
solute carrier (SLC) transporters; blood-brain barrier (BBB); amyotrophic lateral sclerosis (ALS); NSC-34 cell lines; taurine transporter (Taut); large amino acid transporter 1 (LAT1); monocarboxylate transporters (MCTs); organic cation transporters (OCTNs); choline transporter-like protein-1 (CTL1)
Citation
PHARMACEUTICS, v.14, no.10
Journal Title
PHARMACEUTICS
Volume
14
Number
10
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/152381
DOI
10.3390/pharmaceutics14102167
ISSN
1999-4923
1999-4923
Abstract
Defective solute carrier (SLC) transporters are responsible for neurotransmitter dysregulation, resulting in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). We provided the role and kinetic parameters of transporters such as ASCTs, Taut, LAT1, CAT1, MCTs, OCTNs, CHT, and CTL1, which are mainly responsible for the transport of essential nutrients, acidic, and basic drugs in blood-brain barrier (BBB) and motor neuron disease. The affinity for LAT1 was higher in the BBB than in the ALS model cell line, whereas the capacity was higher in the NSC-34 cell lines than in the BBB. Affinity for MCTs was lower in the BBB than in the NSC-34 cell lines. CHT in BBB showed two affinity sites, whereas no expression was observed in ALS cell lines. CTL1 was the main transporter for choline in ALS cell lines. The half maximal inhibitory concentration (IC50) analysis of [H-3]choline uptake indicated that choline is sensitive in TR-BBB cells, whereas amiloride is most sensitive in ALS cell lines. Knowledge of the transport systems in the BBB and motor neurons will help to deliver drugs to the brain and develop the therapeutic strategy for treating CNS and neurological diseases.
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