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췌장암 세포에서 치자나무 열매의 세포주기 정지 및 활성 성분의 세포증식억제Cell cycle arrest by Gardenia jasminoides fruit and anti-proliferative activity by its active components in pancreatic cancer PANC-1 cells
- Other Titles
- Cell cycle arrest by Gardenia jasminoides fruit and anti-proliferative activity by its active components in pancreatic cancer PANC-1 cells
- Issue Date
- Oct-2022
- Publisher
- 한국식품과학회
- Keywords
- Gardenia jasminoides; cell cycle arrest; pancreatic cancer; polyphenol
- Citation
- 한국식품과학회지, v.54, no.5, pp 555 - 560
- Pages
- 6
- Journal Title
- 한국식품과학회지
- Volume
- 54
- Number
- 5
- Start Page
- 555
- End Page
- 560
- ISSN
- 0367-6293
- Abstract
- The ethyl acetate fraction of Gardenia jasminoides fruit (GJF) showed S-phase arrest of cell cycle in pancreatic cancer PANC-1 cells. GJF also reduced the levels of cell cycle regulatory proteins, such as cyclin B1, cyclin D1, and FoxM1, in PANC-1 cells and suppressed cell viability. Furthermore, the cell viability of PANC-1 cells was reduced by geniposide and 4,5-dicaffeoylquinic acid, which were detected in GJF by HPLC analysis. These results suggested that GJF has anti-proliferative activity via cell cycle arrest and regulation of cell cycle-related proteins in PANC-1 pancreatic cancer cells, and these effects of GJF might be partially attributed to geniposide and 4,5-dicaffeoylquinic acid.
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