내분비장애물질노출이 유방암에 미치는 영향 -비스페놀 A를 중심으로

Abstract

Incidence ratio of breast cancer to total cancer has been increased in late 2 decades in Korea and breast cancer ranks second as a cause of death in women in recent Korea. In addition, exposure to endocrine disruptors has been emphasized as a new etiology of breast cancer. In this study, the effects of bisphenol A exposure on breast cancer in Korean women (100 breast cancer patients; 100 hospital controls) were investigated. Conjugated form of blood bisphenol A was designated as an exposure biomarker and analyzed with HPLC/FD. As results, blood bisphenol A could be detected in 94% of the subjects and the range of blood bisphenol A was 0.69～33.7μg/L (median, 5.3μg/L). The geomeric mean of bisphenol A was somewhat higher in the cases than that in the controls, however, was not statistically significant due to multivariate analysis including age, alcohol dringking, breast feeding, and age of menarche. Thus, bisphenol A exposure may not work as a breast cancer risk factor. (Cancer Prev Res 11, 273-277, 2006)