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낙엽송층버섯으로부터 Ergosterol 유도체의 분리 및 RAW 264.7 세포주의 Nitric Oxide 생성 저해활성Inhibition of Nitric Oxide Synthesis by Ergosterol Derivative from Phellinus pini in LPS-ActivatedRAW 264.7 Cells

Other Titles
Inhibition of Nitric Oxide Synthesis by Ergosterol Derivative from Phellinus pini in LPS-ActivatedRAW 264.7 Cells
Authors
장현진양기숙
Issue Date
Dec-2006
Publisher
대한약학회
Keywords
Phellinus pini; ergosta-4; 6; 8(14); 22-tetraen-3-one; nitric oxide; RAW 264.7 cells
Citation
약 학 회 지, v.50, no.6, pp 367 - 371
Pages
5
Journal Title
약 학 회 지
Volume
50
Number
6
Start Page
367
End Page
371
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15279
ISSN
0377-9556
Abstract
Phellinus pini (Hymenocaetaceae) has ben used for the immunomodulating activity, hypolipidemic effect, gas-tric cancer, non-insulin dependant diabetes, diarhea, and menstrual irregularity. From the screening of each fraction for theinhibitory activity of NO production in lipopolysacaride (LPS) activated RAW 264.7 cells, methanol extract of Phellinus piniand hexane soluble fraction exhibited inhibition of NO production compared with LPS control without toxicity. The hexanehexane fr. was repeatedly chromatographed over silica gel, ergosta-4,6,8(14),22- tetraen-3-one was isolated. The compoundinhibited NOS activation .IC50 : 29.7 uM) and NO production of activated macrophage at 30 uM.Keywords . Phelinus pini, ergosta-4,6,8(14),22-tetraen-3-one, nitric oxide, RAW 264.7 cells...... Phellinus pini(Brot ex Fr.) Ames. .....(Basidiomycotina), ...... (Aphyllophorales), ........ (Hymenochaetaceae)1). ... , ... .. ..... ,... , ... .. .... .... .... .... ... (... ).... .... .. . ... white rot fungus. .... ... ..... lignin. .... ... ... ... ..... , ....... .. .... .. .
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