Myricetin과 Taruine의 병용 투여가 B16F10 세포의 항산화 효소계에 미치는 영향

Abstract

The antioxidant enzyme (AOE) system plays an important role in the defense against oxidative stress damage.To determine whether myricetin or myricetin/taurine can exert antioxidative effects not only by modulating the AOE sys-tem directly but also by scavenging free radical, we investigated the influence of the myricetin and taurine on cell viability,ROS level, activities of different antioxidant enzyme, and the expression of different antioxidant enzyme. As results, the cellviability showed inhibition of the proliferation with treatment of ‘myricetin’ or ‘myricetin with taruine’, respectively, withdose-dependent manner. Compared to control, the treatment of ‘myricetin’ decreased activities and gene expressions ofsuperoxide dismutase (SOD), and glutathione peroxidase (GPx). However, combined treatment of ‘myricetin with taurine’‘myricetin with taurine’ somewhat decreased ROS levels, compared to the treatment of ‘myricetin’. In conclusion, our studyprovides that the combined treatment of different antioxidants can enhance antioxidant effects.Keywords . antioxidant enzyme, myricetin, taurine, ROS