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Synthesis of 6-[2-(benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acid and inhibitory activity on beta-amyloid aggregation
- Issue Date
- Nov-2005
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- indole; Alzheimer's disease; beta-amyloid aggregation
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.28, no.11, pp 1219 - 1223
- Pages
- 5
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 28
- Number
- 11
- Start Page
- 1219
- End Page
- 1223
- ISSN
- 0253-6269
1976-3786
- Abstract
- 6-[2-(Benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acids were designed and synthesized as beta-amyloid (A beta) fibril assembly inhibitors. Their inhibitory activity on A beta, aggregation was evaluated by thioflavin T assay although their activities were insignificant.
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