Regulation of IL-18 expression by CRH in mouse microglial cells
- Authors
- Yang, Y; Hahm, E; Kim, Y; Kang, J; Lee, W; Han, I; Myung, P; Kang, H; Park, H; Cho, D
- Issue Date
- May-2005
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- CRH; IL-18; microglia; BV2; ROI
- Citation
- IMMUNOLOGY LETTERS, v.98, no.2, pp 291 - 296
- Pages
- 6
- Journal Title
- IMMUNOLOGY LETTERS
- Volume
- 98
- Number
- 2
- Start Page
- 291
- End Page
- 296
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15505
- DOI
- 10.1016/j.imlet.2004.12.003
- ISSN
- 0165-2478
1879-0542
- Abstract
- Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress. (c) 2004 Elsevier B.V. All rights reserved.
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