Induction of nitric oxide synthase by saponins of heat-processed ginseng
DC Field | Value | Language |
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dc.contributor.author | Kim, JY | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Kim, JS | - |
dc.contributor.author | Ryu, JH | - |
dc.date.available | 2021-02-22T15:46:54Z | - |
dc.date.issued | 2005-05 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15512 | - |
dc.description.abstract | Total saponin of heat-processed ginseng (TSHG) stimulated the production of nitric oxide (NO) in interferon-gamma (IFN-gamma)-primed macrophages through the increased expression of inducible nitric oxide synthase (iNOS). However, TSHG by itself had a very weak effect on the NO synthesis without IFN-gamma priming. The saponins of white ginseng inhibited the NO production in lipopolysaccharide (LPS)/IFN-gamma activated macrophages rather than the stimulation of NO production found in IFN-gamma primed macrophages. The NO production by TSHG-stimulated macrophages was inhibited by the NOS inhibitor (N-G-monomethyl-L-arginine (L-NMMA)) and nuclear factor-kappaB inhibitor (pyrrolidine dithiocarbamate (PDTC)). TSHG showed different serum-dependence from LPS on the activation of IFN-gamma primed macrophages. This property of TSHG may explain the intensified anti-tumor properties of heat-processed ginseng through its immunostimulating activity. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Induction of nitric oxide synthase by saponins of heat-processed ginseng | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1271/bbb.69.891 | - |
dc.identifier.scopusid | 2-s2.0-22444450378 | - |
dc.identifier.wosid | 000229575000004 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.69, no.5, pp 891 - 895 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 69 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 891 | - |
dc.citation.endPage | 895 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | RAT GLIOMA-CELLS | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | ginseng | - |
dc.subject.keywordAuthor | heat processing | - |
dc.subject.keywordAuthor | nitric oxide synthase | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | saponin | - |
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