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Induction of nitric oxide synthase by saponins of heat-processed ginseng

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dc.contributor.authorKim, JY-
dc.contributor.authorLee, HJ-
dc.contributor.authorKim, JS-
dc.contributor.authorRyu, JH-
dc.date.available2021-02-22T15:46:54Z-
dc.date.issued2005-05-
dc.identifier.issn0916-8451-
dc.identifier.issn1347-6947-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15512-
dc.description.abstractTotal saponin of heat-processed ginseng (TSHG) stimulated the production of nitric oxide (NO) in interferon-gamma (IFN-gamma)-primed macrophages through the increased expression of inducible nitric oxide synthase (iNOS). However, TSHG by itself had a very weak effect on the NO synthesis without IFN-gamma priming. The saponins of white ginseng inhibited the NO production in lipopolysaccharide (LPS)/IFN-gamma activated macrophages rather than the stimulation of NO production found in IFN-gamma primed macrophages. The NO production by TSHG-stimulated macrophages was inhibited by the NOS inhibitor (N-G-monomethyl-L-arginine (L-NMMA)) and nuclear factor-kappaB inhibitor (pyrrolidine dithiocarbamate (PDTC)). TSHG showed different serum-dependence from LPS on the activation of IFN-gamma primed macrophages. This property of TSHG may explain the intensified anti-tumor properties of heat-processed ginseng through its immunostimulating activity.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherTAYLOR & FRANCIS LTD-
dc.titleInduction of nitric oxide synthase by saponins of heat-processed ginseng-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1271/bbb.69.891-
dc.identifier.scopusid2-s2.0-22444450378-
dc.identifier.wosid000229575000004-
dc.identifier.bibliographicCitationBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.69, no.5, pp 891 - 895-
dc.citation.titleBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY-
dc.citation.volume69-
dc.citation.number5-
dc.citation.startPage891-
dc.citation.endPage895-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaFood Science & Technology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryChemistry, Applied-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.subject.keywordPlusRAT GLIOMA-CELLS-
dc.subject.keywordPlusFACTOR-KAPPA-B-
dc.subject.keywordPlusPANAX-GINSENG-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusLIPOPOLYSACCHARIDE-
dc.subject.keywordPlusACID-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusEXTRACT-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordPlusCANCER-
dc.subject.keywordAuthorginseng-
dc.subject.keywordAuthorheat processing-
dc.subject.keywordAuthornitric oxide synthase-
dc.subject.keywordAuthormacrophage-
dc.subject.keywordAuthorsaponin-
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