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The interferon-inducible 9-27 gene modulates the susceptibility to natural killer cells and the invasiveness of gastric cancer cells
- Authors
- Yang, Young; Lee, JH; Kim, KY; Song, HK; Kim, JK; Yoon, SR; Cho, D; Song, KS; Lee, YH; Choi, I
- Issue Date
- Apr-2005
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- 9-27; natural killer cell; invasion; IFN-gamma
- Citation
- CANCER LETTERS, v.221, no.2, pp 191 - 200
- Pages
- 10
- Journal Title
- CANCER LETTERS
- Volume
- 221
- Number
- 2
- Start Page
- 191
- End Page
- 200
- ISSN
- 0304-3835
1872-7980
- Abstract
- As an effort to identify immune suppressive molecules in gastric cancer cells, a signal sequence trap was employed. Among the genes identified, 9-27 gene was highly expressed in gastric tumor tissues and in cancer cell lines. It was induced by IFN-gamma treatment, but not by TNF-alpha or TGF-beta 1 treatment. The overexpression of 9-27 in the gastric cancer cells rendered tumor cells more resistant to natural killer cells. In addition, the 9-27-overexpressed cells showed an increased migration and an invasive capacity when compared with the control cells. Taken together, these data indicate that 9-27 plays a role in malignant progression by suppressing natural killer cells and by increasing the invasive potential of gastric cancer cells. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
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- 이과대학 > 생명시스템학부 > 1. Journal Articles
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