Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris
- Authors
- Won, SY; Park, EH
- Issue Date
- Jan-2005
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- anti-inflammatory; antinociceptive; anti-angiogenic; cordycepin; antioxidant; inducible nitric oxide synthase; Cordycecps militaris
- Citation
- JOURNAL OF ETHNOPHARMACOLOGY, v.96, no.3, pp 555 - 561
- Pages
- 7
- Journal Title
- JOURNAL OF ETHNOPHARMACOLOGY
- Volume
- 96
- Number
- 3
- Start Page
- 555
- End Page
- 561
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15549
- DOI
- 10.1016/j.jep.2004.10.009
- ISSN
- 0378-8741
1872-7573
- Abstract
- This study aimed to elucidate pharmacological activities of Cordyceps militaris. The 70% ethanolic extracts of cultured mycelia (CME) and fruiting bodies (FBE) of Cordyceps militaris were prepared. CME was able to directly scavenge the stable free radical diphenyt-2-picrylhydrazyl (DPPH), indicating its antioxidant activity. Both CME and FBE showed topical anti-inflammatory activity in the croton oil-induced ear edema in mice. CME was found to contain acute anti-inflammatory activity, which was evaluated using the carrageenin-induced edema, and also strong antinociceptive activity in writhing test. CME and FBE contain potent inhibitory activity on the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner. Cordycepin, a metabolite of Cordyceps militaris, appeared to be at least partly responsible for its anti-inflammatory and anti-angiogenic activities. CME concentration-dependently inhibited the NO production and iNOS expression upon stimulation by lipoposaccharide in RAW 264.7, a murine macrophage cell line. In brief, we demontrate that Cordyceps militaris possesses anti-inflammatory and antinociceptive activites, and related antioxidant, anti-angiogenic, and NO production-inhibitory activities. (C) 2004 Published by Elsevier Ireland Ltd.
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