배의 메탄올 추출물이 마우스의 비장세포 증식능과 Cytokine 생성능에 미치는 영향Effects of Pear (Pyrus pyrifolia) Methanol Extracts on the Proliferation and the Cytokines Productionof Mouse Splenocytes
- Other Titles
- Effects of Pear (Pyrus pyrifolia) Methanol Extracts on the Proliferation and the Cytokines Productionof Mouse Splenocytes
- Authors
- 황유경; 표명윤
- Issue Date
- Feb-2005
- Publisher
- 대한약학회
- Keywords
- pear; splenocytes proliferation; IFN-g; IL-4
- Citation
- 약 학 회 지, v.49, no.1, pp 25 - 29
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 49
- Number
- 1
- Start Page
- 25
- End Page
- 29
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15698
- ISSN
- 0377-9556
- Abstract
- This study was performed to investigate the potential of pear (Pyrus pyrifolia) as a immune-modulating functional food by assay of splenocytes proliferation and induction of cytokines (IFN-g, IL-4) in vitro. When mouse splenocytes were exposed to various concentration (0.16, 0.31, 0.63, 1.25, 2.50 mg/ml) of pear methanol extracts (P-M) without mitogens, splenocytes proliferation (SP) was significantly increased. Also, SP to mitogens, concanavalin A (Con A) and lipopolysaccharide (LPS) were significantly increased by P-M when compared with controls. When splenocytes were cultured with P-M in the presence of Con A, cytokine (IFN-g, IL-4) levels in culture supernatant were significantly enhanced in a dose-dependent manner except 2.5 mg/ml when compared with control group. Therefore, our study suggest that the pear has the potential of being an immune-modulating functional food.
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