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파골세포 분화에 관여하는 phosphodiesterase isozyme의 규명Identification of Phosphodiesterase Isozyme Involved in Osteoclast Formation
- Other Titles
- Identification of Phosphodiesterase Isozyme Involved in Osteoclast Formation
- Issue Date
- Oct-2004
- Publisher
- 숙명여자대학교 약학연구소
- Citation
- 약학논문집-숙명여자대학교, v.21, pp 109 - 113
- Journal Title
- 약학논문집-숙명여자대학교
- Volume
- 21
- Start Page
- 109
- End Page
- 113
- ISSN
- 1225-3723
- Abstract
- Phosphodiesterases (PDEs) are enzymes that degrade intracellular cAMP and cGMP. In the present study, inhibition of PDE4 was demonstrated to influence osteoclast formation in co-cultures of mouse bone marrow cells and calvarial osteoblasts. Furthermore, PDE4 was shown to modulate mRNA expression of EP4, TRANCE, and COX-2 in calvarial osteoblasts. These results suggest that PDE4 is a key regulator of EP4, TRANCE, and COX-2 expression in osteoblasts, which in turn controls osteoclast formation.
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