Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus
- Authors
- Kim, SH; 송윤선; Kim, SK; Kim, BC; Lim, CJ; Park, EH
- Issue Date
- Jul-2004
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Phellinus linteus; anti-inflammatory; antinociceptive; anti-angiogenic; chorioallantoic membrane; ear edema; folk medicine
- Citation
- JOURNAL OF ETHNOPHARMACOLOGY, v.93, no.1, pp 141 - 146
- Pages
- 6
- Journal Title
- JOURNAL OF ETHNOPHARMACOLOGY
- Volume
- 93
- Number
- 1
- Start Page
- 141
- End Page
- 146
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/15857
- DOI
- 10.1016/j.jep.2004.03.048
- ISSN
- 0378-8741
1872-7573
- Abstract
- This study aimed to elucidate the anti-inflammatory and related activities of mushroom Phellinus linteus. The results show that the EtOH extract of Phellinus linteus (PLE) dose-dependently inhibited the mouse ear edema induced by croton oil. Among PLE subfractions, the n-BuOH subtraction showed highest anti-inflammatory activity in croton oil-induced ear edema test. The n-BuOH subtraction also showed highest inhibitory activity on the chick embryo chorioallantoic membrane (CAM) angiogenesis in a dose-dependent manner. PLE could significantly reduce the number of writhing induced by acetic acid in mice, indicating that PLE possesses potent antinociceptive effect mediated by its anti-inflammatory activity. Mycelial extract of six different Phellinus strains were found to contain anti-angiogenic activity in the CAM assay. These results suggest that Phellinus linteus has anti-inflammatory and antinociceptive activities, in addition to its anti-angiogenic activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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