Detailed Information
Cited 0 time in 
Cited 11 time in 
Cited 11 time in
Metadata Downloads
N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands
- Authors
- Park, HG; Choi, JY; Choi, SH; Park, MK; Lee, J; Suh, YG; Cho, H; Oh, U; Kim, HD; Joo, YH; Kim, SY; Park, YH; Jeong, YS; Choi, JK; Kim, JK; Jew, SS
- Issue Date
- Apr-2004
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- vanilloid receptor; antagonist; structure-activity relationship
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.14, no.7, pp 1693 - 1696
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 14
- Number
- 7
- Start Page
- 1693
- End Page
- 1696
- ISSN
- 0960-894X
1464-3405
- Abstract
- A series of N-4-methansulfonamidobenzyl-M-2-substituted-4-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG neurons. Their structure-activity relationship reveals that there is a space for another hydrophobic binding interaction around 2-position in 4-tert-butylbenzyl region. Among the prepared derivatives, 6n show the highest antagonistic activity against the vanilloid receptor (IC50 = 15 nM). (C) 2004 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.