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아세트아미노펜 정제의 초기용출 비교연구Comparative Study on Initial Dissolution Rate of Acetaminophen Tablets
- Other Titles
- Comparative Study on Initial Dissolution Rate of Acetaminophen Tablets
- Authors
- 오승열
- Issue Date
- Feb-2003
- Publisher
- 숙명여자대학교 약학연구소
- Citation
- 숙명여자대학교 약학논문집, v.19, pp 61 - 66
- Pages
- 6
- Journal Title
- 숙명여자대학교 약학논문집
- Volume
- 19
- Start Page
- 61
- End Page
- 66
- ISSN
- 1225-3723
- Abstract
- We have studied the initial dissolution kinetics of 9 marketed acetaminophen tablets in simulated gastric fluid and pH 5.8 solution, and the dissolution profiles were compared. Dissolution for the first 5 minutes from tablet J was significantly faster (p<0.01) in all sampling points than the rest of the tablets, indicating that the fast releasing component of this sustained tablet rapidly dissolves in both medium. Tablet C also showed fast dissolution, when compared to others. Considering the point that acetaminophen is a drug for antipyretic/analgesic effect and rapid dissolution can be advantageous, it seems necessary for some tablets to be improved for faster dissoluton.
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Collections - 약학대학 > 약학부 > 1. Journal Articles
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