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Effects of major dietary antioxidants on inflammatory markers of RAW 264.7 macrophages

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dc.contributor.authorJung, WJ-
dc.contributor.authorSung, MK-
dc.date.available2021-02-22T16:16:46Z-
dc.date.created2020-09-01-
dc.date.issued2004-
dc.identifier.issn0951-6433-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16131-
dc.description.abstractOxidative stresses are involoved in the process of chronic inflammatory diseases. The objective of this study was to evaluate and compare the anti-inflammatory activity of major dietary antioxidants. Murine RAW264.7 macrophages (4 X 10(6) cells) were incubated in DMEM containing 10% FBS supplemented with 5 to 20 muM of alpha-tocopherol, beta-carotene or quercetin for 24 hrs, and then treated with LPS for 16hrs. The medium was collected to measure TNF-alpha, IL-6, PGE(2) and nitrite. Expressions of cyclooxygenase-2(COX-2) and inducible nitric oxide synthase(iNOS) were determined using the harvested cells. Results indicate that TNF-alpha and IL-6 accumulations were significantly reduced by 5 to 20 muM quercetin treatment, and 20 muM of alpha-tocopherol treatment. Nitrite release was significantly reduced by 5 muM quercetin treatment. However, PGE(2) accumulation was not affected by any of the antioxidants used. Expressions of COX-2 and iNOS were effectively reduced by 5 muM quercetin treatment. These findings indicate that dietary antioxidants possess significant anti-inflammatory activities, and quercetin is the most potent antioxidant.-
dc.language영어-
dc.language.isoen-
dc.publisherWILEY-
dc.subjectNF-KAPPA-B-
dc.subjectFLAVONOIDS-
dc.subjectEXPRESSION-
dc.titleEffects of major dietary antioxidants on inflammatory markers of RAW 264.7 macrophages-
dc.typeArticle-
dc.contributor.affiliatedAuthorSung, MK-
dc.identifier.doi10.1002/biof.552210122-
dc.identifier.scopusid2-s2.0-16444364508-
dc.identifier.wosid000227306700021-
dc.identifier.bibliographicCitationBIOFACTORS, v.21, no.1-4, pp.113 - 117-
dc.relation.isPartOfBIOFACTORS-
dc.citation.titleBIOFACTORS-
dc.citation.volume21-
dc.citation.number1-4-
dc.citation.startPage113-
dc.citation.endPage117-
dc.type.rimsART-
dc.type.docTypeArticle; Proceedings Paper-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaEndocrinology & Metabolism-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryEndocrinology & Metabolism-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusFLAVONOIDS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordAuthorantioxidants-
dc.subject.keywordAuthorinflammation-
dc.subject.keywordAuthormacrophages-
dc.subject.keywordAuthorinflammatory cytokines-
dc.subject.keywordAuthorCOX-2-
dc.subject.keywordAuthoriNOS-
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