Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Age-related changes in the activity of antioxidant and redox enzymes in rats

Authors
Kim, HGHong, SMKim, SJPark, HJJung, HILee, YYMoon, JSLim, HWPark, EHLim, CJ
Issue Date
31-Dec-2003
Publisher
SPRINGER-VERLAG SINGAPORE PTE LTD
Keywords
aging; antioxidant; brain; cellular defense system; liver; rat; redox enzyme
Citation
MOLECULES AND CELLS, v.16, no.3, pp.278 - 284
Journal Title
MOLECULES AND CELLS
Volume
16
Number
3
Start Page
278
End Page
284
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16135
ISSN
1016-8478
Abstract
Cellular defense system, including glutathione, glutathione-related enzymes, and antioxidant and redox enzymes, may play crucial roles in the aging of aerobic organisms. To understand the physiological roles of these factors in the aging process, their levels were compared in the livers and brains of 5-week- and 9-month-old rats. GST activity was higher in livers and brains of 9-month-old rats than in those of 5-week-old rats, and brain catalase activity was about 2-fold higher. However, it was unchanged in the livers of the 9-month-old rats. gamma-Glutamylcysteine synthetase activity was about 2-fold higher in the brains of the older rats but again not in their livers. In contrast glutathione synthetase activity appeared to be lower in the livers of the older rats while GSH content did not change with,age in livers and brains. Glutathione peroxidase activity was higher in 9-month-old rat brains, but lower in 9-month-old rat livers; while superoxide dismutase activity was higher in both tissues in the older rats. The activities of two redox enzymes, thioltransferase and thioredoxin reductase, did,not change with age, nor did that of glutathione reductase. These results indicate that levels of different cellular defense systems vary with age in an irregular manner.
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE