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Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects

Authors
Suh, YGLee, YSMin, KHPark, OHSeung, HSKim, HDPark, HGChoi, JYLee, JWKang, SWOh, UTKoo, JYJoo, YHKim, SYKim, JKPark, YH
Issue Date
Dec-2003
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.24, pp 4389 - 4393
Pages
5
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume
13
Number
24
Start Page
4389
End Page
4393
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16136
DOI
10.1016/j.bmcl.2003.09.024
ISSN
0960-894X
1464-3405
Abstract
A novel non-vanilloid VR1 antagonist consisting of a new vanilloid equivalent exhibits excellent analgesic effects as well as highly potent antagonistic activities in both capsaicin single channel and calcium uptake assays. In addition, the structural requirement for the vanilloid equivalent of the potent VR1 antagonist has also been elucidated. (C) 2003 Elsevier Ltd. All rights reserved.
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