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Gender differences in the levels of bisphenol A metabolites in urine

Authors
Kim, YHKim, CSPark, SHan, SYPyo, MYYang, MH
Issue Date
12-Dec-2003
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
bisphenol A; endocrine disruptor; beta-glueuronidase; sulfatase; urinary conjugates
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.312, no.2, pp.441 - 448
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
312
Number
2
Start Page
441
End Page
448
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16137
DOI
10.1016/j.bbrc.2003.10.135
ISSN
0006-291X
Abstract
The metabolism of bisphenol A (BPA), a suspected endocrine disruptor, should be considered for monitoring human exposure to BPA, because the conjugation with beta-D-glucuronide and sulfate reduces the estrogenic activity. In this study, BPA levels in 30 healthy Koreans (men, N = 15, 42.6 +/- 2.4 years; women, N = 15, 43.0 +/- 2.7 years) were analyzed from urine treated with/without beta-glucuronidase and/or sulfatase by an RP-HPLC with fluorescence detection. The total BPA concentrations including free BPA and the urinary conjugates were similar in men and women (2.82 +/- 0.73 and 2.76 +/- 0.54 ng ml(-1), respectively), but gender differences were found in the levels of urinary BPA conjugates. Men had significantly higher levels of BPA-glucuronide (2.34 +/- 0.85 ng ml-1) than women (1.00 +/- 0.34 ng ml(-1)), whereas women had higher levels of BPA-sulfate (1.20 +/- 0.32 ng ml(-1)) than men (0.49 +/- 0.27 ng ml(-1)). (C) 2003 Elsevier Inc. All rights reserved.
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