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Synthesis and biological evaluation of thymine nucleosides fused with 3 ',4 '-tetrahydrofuran ring

Authors
Kim, MJKim, HOKim, HDKim, JHJeong, LSChun, MW
Issue Date
20-Oct-2003
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.20, pp.3499 - 3501
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume
13
Number
20
Start Page
3499
End Page
3501
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16156
DOI
10.1016/S0960-894X(03)00730-3
ISSN
0960-894X
Abstract
The pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were successfully synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities against HIV-1, HIV-2, EMCV, Cox. B3 and VSV. Thymine analogue (5) and its corresponding 2'-deoxy analogue (6) exhibited high cytotoxicity instead of giving antiviral activities. (C) 2003 Elsevier Ltd. All rights reserved.
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