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The EphA8 receptor phosphorylates and activates low molecular weight phosphotyrosine protein phosphatase in vitro

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dc.contributor.authorPark, S-
dc.date.available2021-02-22T16:17:35Z-
dc.date.issued2003-05-
dc.identifier.issn1225-8687-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16188-
dc.description.abstractLow molecular weight phosphotyrosine protein phosphatase (LMW-PTP) has been implicated in modulating the EphB1-mediated signaling pathway. In this study, we demonstrated that the EphA8 receptor phosphorylates LMW-PTP in vitro. In addition, we discovered that mixing these two proteins leads to EphA8 dephosphorylation in the absence of phosphatase inhibitors. Finally, we demonstrated that LMW-PTP, modified by the EphA8 autokinase activity, possesses enhanced catalytic activity in vitro. These results suggest that LMW-PTP may also participate in a feedback-control mechanism of the EphA8 receptor autokinase activity in vivo.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherSPRINGER-VERLAG SINGAPORE PTE LTD-
dc.titleThe EphA8 receptor phosphorylates and activates low molecular weight phosphotyrosine protein phosphatase in vitro-
dc.typeArticle-
dc.publisher.location싱가폴-
dc.identifier.doi10.5483/BMBRep.2003.36.3.288-
dc.identifier.scopusid2-s2.0-0038119084-
dc.identifier.wosid000183187300008-
dc.identifier.bibliographicCitationJOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, v.36, no.3, pp 288 - 293-
dc.citation.titleJOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY-
dc.citation.volume36-
dc.citation.number3-
dc.citation.startPage288-
dc.citation.endPage293-
dc.type.docTypeArticle-
dc.identifier.kciidART000887690-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.subject.keywordPlusREGULATES INTEGRIN ACTIVITY-
dc.subject.keywordPlusTYROSINE KINASE-ACTIVITY-
dc.subject.keywordPlusGROWTH-FACTOR-
dc.subject.keywordPlusR-RAS-
dc.subject.keywordPlusLIGAND-
dc.subject.keywordPlusATTACHMENT-
dc.subject.keywordPlusADHESION-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusEPHRINS-
dc.subject.keywordAuthorEph-
dc.subject.keywordAuthorEphA8-
dc.subject.keywordAuthorLMW-PTP-
dc.subject.keywordAuthortyrosine kinase receptor-
dc.identifier.urlhttps://www.koreascience.or.kr/article/JAKO200309137568836.page-
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