The EphA8 receptor phosphorylates and activates low molecular weight phosphotyrosine protein phosphatase in vitro
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, S | - |
dc.date.available | 2021-02-22T16:17:35Z | - |
dc.date.issued | 2003-05 | - |
dc.identifier.issn | 1225-8687 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16188 | - |
dc.description.abstract | Low molecular weight phosphotyrosine protein phosphatase (LMW-PTP) has been implicated in modulating the EphB1-mediated signaling pathway. In this study, we demonstrated that the EphA8 receptor phosphorylates LMW-PTP in vitro. In addition, we discovered that mixing these two proteins leads to EphA8 dephosphorylation in the absence of phosphatase inhibitors. Finally, we demonstrated that LMW-PTP, modified by the EphA8 autokinase activity, possesses enhanced catalytic activity in vitro. These results suggest that LMW-PTP may also participate in a feedback-control mechanism of the EphA8 receptor autokinase activity in vivo. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER-VERLAG SINGAPORE PTE LTD | - |
dc.title | The EphA8 receptor phosphorylates and activates low molecular weight phosphotyrosine protein phosphatase in vitro | - |
dc.type | Article | - |
dc.publisher.location | 싱가폴 | - |
dc.identifier.doi | 10.5483/BMBRep.2003.36.3.288 | - |
dc.identifier.scopusid | 2-s2.0-0038119084 | - |
dc.identifier.wosid | 000183187300008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, v.36, no.3, pp 288 - 293 | - |
dc.citation.title | JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY | - |
dc.citation.volume | 36 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 288 | - |
dc.citation.endPage | 293 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART000887690 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | REGULATES INTEGRIN ACTIVITY | - |
dc.subject.keywordPlus | TYROSINE KINASE-ACTIVITY | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | R-RAS | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | ATTACHMENT | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | EPHRINS | - |
dc.subject.keywordAuthor | Eph | - |
dc.subject.keywordAuthor | EphA8 | - |
dc.subject.keywordAuthor | LMW-PTP | - |
dc.subject.keywordAuthor | tyrosine kinase receptor | - |
dc.identifier.url | https://www.koreascience.or.kr/article/JAKO200309137568836.page | - |
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