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Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates

Authors
Wender, PAJeon, R
Issue Date
19-May-2003
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.10, pp.1763 - 1766
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume
13
Number
10
Start Page
1763
End Page
1766
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16189
DOI
10.1016/S0960-894X(03)00212-9
ISSN
0960-894X
Abstract
Bromofluoroacetophenone derivatives which produce fluorine substituted phenyl radicals that cleave DNA upon excitation were investigated as a novel photonuclease. Pyrrolecarboxamide-conjugated bromofluoroacetophenones; 4'-bromo-2'-fluoroacetophenone and 2'-bromo-4'-fluoroacetophenone were synthesized and their DNA cleaving activities and sequence selectivities were determined. Bromofluoroacetophenone-pyrrolecarboxamide conjugates were. found to be effective DNA cleaving agents upon irradiation in concentration dependent manner based on plasma relaxation assay. The DNA cleaving activities of 2'-bromo-4'-fluoroacetophenone derivatives were larger than those of 4'-bromo-2'-fluoroacetophenone derivatives. (C) 2003 Elsevier Science Ltd. All rights reserved.
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