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Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists

Authors
Yoon, JChoi, HLee, HJRyu, CHPark, HGSuh, YGOh, UJeong, YSChoi, JKPark, YHKim, HD
Issue Date
5-May-2003
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.9, pp.1549 - 1552
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume
13
Number
9
Start Page
1549
End Page
1552
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16193
DOI
10.1016/S0960-894X(03)00178-1
ISSN
0960-894X
Abstract
A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched le showed a 6.3 muM Of IC50 value in Ca-45(2+)-influx assay. (C) 2003 Elsevier Science Ltd. All rights reserved.
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