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Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists
- Authors
- Yoon, J; Choi, H; Lee, HJ; Ryu, CH; Park, HG; Suh, YG; Oh, U; Jeong, YS; Choi, JK; Park, YH; Kim, HD
- Issue Date
- May-2003
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.9, pp 1549 - 1552
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 13
- Number
- 9
- Start Page
- 1549
- End Page
- 1552
- ISSN
- 0960-894X
1464-3405
- Abstract
- A series of acyclic phenethylthiocarbamate derivatives have been synthesized, and their antagonist effect against vanilloid receptor tested. Chain branching led to a significant change in antagonist activity of the parent molecule. Ethyl-branched le showed a 6.3 muM Of IC50 value in Ca-45(2+)-influx assay. (C) 2003 Elsevier Science Ltd. All rights reserved.
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