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The p110 gamma PI-3 kinase is required for EphA8-stimulated cell migration

Authors
Gu, CPark, S
Issue Date
Apr-2003
Publisher
ELSEVIER SCIENCE BV
Keywords
Eph; ephrin; p110 gamma PI-3 kinase
Citation
FEBS LETTERS, v.540, no.1-3, pp.65 - 70
Journal Title
FEBS LETTERS
Volume
540
Number
1-3
Start Page
65
End Page
70
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16198
DOI
10.1016/S0014-5793(03)00223-0
ISSN
0014-5793
Abstract
This study provides evidence that treatment with preclustered ephrin A5-Fc results in a substantial increase in the stability of the p110gamma PI-3 kinase associated with EphA8, thereby enhancing PI-3 kinase activity and cell migration on a fibronectin substrate. In contrast, co-expression of a lipid kinase-inactive p110gamma mutant together with EphA8 inhibits ligand-stimulated PI-3 kinase activity and cell migration on a fibronectin substrate, suggesting that the mutant has a dominant negative effect against the endogenous p110gamma PI-3 kinase. Significantly, the tyrosine kinase activity of EphA8 is not important for either of these processes. Taken together, our results demonstrate that the stimulation of cell migration on a fibronectin substrate by the EphA8 receptor depends on the p110gamma PI-3 kinase but is independent of a tyrosine kinase activity. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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