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Butanolides from Machilus thunbergii and their inhibitory activity on nitric oxide synthesis in activated macrophages

Authors
Kim, NYRyu, JH
Issue Date
Apr-2003
Publisher
JOHN WILEY & SONS LTD
Keywords
Machilus thunbergii; butanolide; nitric oxide synthase; lipopolysaccharide; inhibitor
Citation
PHYTOTHERAPY RESEARCH, v.17, no.4, pp 372 - 375
Pages
4
Journal Title
PHYTOTHERAPY RESEARCH
Volume
17
Number
4
Start Page
372
End Page
375
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16200
DOI
10.1002/ptr.1160
ISSN
0951-418X
1099-1573
Abstract
In activated macrophages the inducible form of nitric oxide synthase (iNOS) generates high amounts of the toxic mediator, nitric oxide (NO), that contributes to the circulatory failure associated with septic shock. Three butanolides were isolated from Machilus thunbergii as active principles which inhibit the production of NO in lipopolysaccharide-activated RAW 264.7 cells, and their structures were identified as litsenolide A2 (1), B1 (2) and B2 (3). They showed dose-dependent inhibition of NO syntheses and the IC(50)s were 3.36, 3.70 and 6.19 mum, respectively. These new inhibitors of iNOS may have potential in the treatment of endotoxaemia and inflammation accompanied by the overproduction of NO. Copyright (C) 2003 John Wiley Sons, Ltd.
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