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Synthesis of N,N ',N ''-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor
- Authors
- Park, H; Park, M; Choi, J; Choi, S; Lee, J; Park, B; Kim, MG; Suh, Y; Cho, H; Oh, U; Lee, J; Kim, HD; Park, YH; Koh, HJ; Lim, KM; Moh, JH; Jew, S
- Issue Date
- Feb-2003
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.4, pp 601 - 604
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 13
- Number
- 4
- Start Page
- 601
- End Page
- 604
- ISSN
- 0960-894X
1464-3405
- Abstract
- Twenty-seven N,N',N"-trisubstituted thiourea derivatives were prepared. Among them, 1-[3-(4'-hydroxy-3'-methoxy- phenyl)-propyl]-1.3-diphenethyl-thiourea (81, IC50=0.32 muM), showed 2-fold higher antagonistic actively than that of capsazepine (3, IC50 = 0.65 muM) against the,anilloid receptor in a Ca-45(2+)-influx assay. (C) 2003 Elsevier Science Ltd. All rights reserved.
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