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Synthesis of N,N ',N ''-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor

Authors
Park, HPark, MChoi, JChoi, SLee, JPark, BKim, MGSuh, YCho, HOh, ULee, JKim, HDPark, YHKoh, HJLim, KMMoh, JHJew, S
Issue Date
24-Feb-2003
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.4, pp.601 - 604
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume
13
Number
4
Start Page
601
End Page
604
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16216
DOI
10.1016/S0960-894X(02)01040-5
ISSN
0960-894X
Abstract
Twenty-seven N,N',N"-trisubstituted thiourea derivatives were prepared. Among them, 1-[3-(4'-hydroxy-3'-methoxy- phenyl)-propyl]-1.3-diphenethyl-thiourea (81, IC50=0.32 muM), showed 2-fold higher antagonistic actively than that of capsazepine (3, IC50 = 0.65 muM) against the,anilloid receptor in a Ca-45(2+)-influx assay. (C) 2003 Elsevier Science Ltd. All rights reserved.
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