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Synthesis of N,N ',N ''-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor

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dc.contributor.authorPark, H-
dc.contributor.authorPark, M-
dc.contributor.authorChoi, J-
dc.contributor.authorChoi, S-
dc.contributor.authorLee, J-
dc.contributor.authorPark, B-
dc.contributor.authorKim, MG-
dc.contributor.authorSuh, Y-
dc.contributor.authorCho, H-
dc.contributor.authorOh, U-
dc.contributor.authorLee, J-
dc.contributor.authorKim, HD-
dc.contributor.authorPark, YH-
dc.contributor.authorKoh, HJ-
dc.contributor.authorLim, KM-
dc.contributor.authorMoh, JH-
dc.contributor.authorJew, S-
dc.date.available2021-02-22T16:17:58Z-
dc.date.issued2003-02-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16216-
dc.description.abstractTwenty-seven N,N',N"-trisubstituted thiourea derivatives were prepared. Among them, 1-[3-(4'-hydroxy-3'-methoxy- phenyl)-propyl]-1.3-diphenethyl-thiourea (81, IC50=0.32 muM), showed 2-fold higher antagonistic actively than that of capsazepine (3, IC50 = 0.65 muM) against the,anilloid receptor in a Ca-45(2+)-influx assay. (C) 2003 Elsevier Science Ltd. All rights reserved.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleSynthesis of N,N ',N ''-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/S0960-894X(02)01040-5-
dc.identifier.scopusid2-s2.0-0037294166-
dc.identifier.wosid000180998900002-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.4, pp 601 - 604-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume13-
dc.citation.number4-
dc.citation.startPage601-
dc.citation.endPage604-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusANALGESIC AGENTS-
dc.subject.keywordPlusAGONIST ACTIVITY-
dc.subject.keywordPlusCAPSAICIN ANALOGS-
dc.subject.keywordPlusTAIL INVITRO-
dc.subject.keywordPlusRESINIFERATOXIN-
dc.subject.keywordPlusREGION-
dc.subject.keywordPlusRAT-
dc.subject.keywordPlusFIBERS-
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