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마우스에서 Bisphenol A의 아급성노출이 IgM-PFC형성능과 비장세포 증식능에 미치는 영향Effects of Subacute Oral Administration of Bisphenol A on the IgM-PFC and Proliferation of Splenocytes in Mice
- Other Titles
- Effects of Subacute Oral Administration of Bisphenol A on the IgM-PFC and Proliferation of Splenocytes in Mice
- Issue Date
- Sep-2003
- Publisher
- 환경독성보건학회
- Keywords
- Bisphenol A; IgM- PFC; splenic proliferation; Bisphenol A; IgM- PFC; splenic proliferation
- Citation
- 환경독성보건학회지, v.18, no.3, pp 231 - 235
- Pages
- 5
- Journal Title
- 환경독성보건학회지
- Volume
- 18
- Number
- 3
- Start Page
- 231
- End Page
- 235
- ISSN
- 2093-6400
- Abstract
- To determine whether or not bisphenol A affects the immune system, female ICR mice were treatedbisphenol A(BPA) orally at the doses of 100, 500 and 1,000mg/kg for 30 consecutive days. Four days beforeenumerating plaque-forming cells (PFCs) mice were immunized intraperitoneally with sheep red blood cells(SRBCs). The spleen cellularity and PFC/spleen were significantly reduced by 30--2, the lymphocyteproliferation ex vivo was not significantly suppressed by BPA. Our present results indicated that 30-dayexposure of mice to BPA might have mild immunotoxic potential.
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