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Two neolignans from Perilla frutescens and their inhibition of nitric oxide synthase and tumor necrosis factor-alpha expression in murine macrophage cell line RAW 264.7

Authors
Ryu, JHSon, HJLee, SHSohn, DH
Issue Date
Feb-2002
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.12, no.4, pp 649 - 651
Pages
3
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume
12
Number
4
Start Page
649
End Page
651
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16432
DOI
10.1016/S0960-894X(01)00812-5
ISSN
0960-894X
1464-3405
Abstract
Two neolignans were isolated from leaves of Perilla fratescens (Labiatae) as inhibitors of nitric oxide syntheses (IC50 5.9 muM and 53.5 muM, respectively) and tumor necrosis factor-alpha in lipopolysaccharide-activated RAW 264.7 cells. Their structures were identified as 1p,2alpha,3beta,4alpha-1,2-dimethyl-3,4-bis-(2,4,5-trimethoxyphenyl)-cyclobutane (magnosalin), and 1alpha,2beta,3beta,4beta-1,2-dimethyl-3,4-bis-(2,4,5-trimethoxyphenyl)-cyclobutane (andamanicin), and their activities were confirmed as resulted from the suppressed expression of inducible nitric oxide synthase enzyme and from the secretion of tumor necrosis factor-alpha from activated macropha. (C) 2002 Elsevier Science Ltd. All rights reserved.
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