Enhanced IL-18 expression in common skin tumors
- Authors
- Park, H; Byun, D; Kim, TS; Kim, YI; Kang, JS; Hahm, ES; Kim, SH; Lee, WJ; Song, HK; Yoon, DY; Kang, CJ; Lee, C; Houh, D; Kim, H; Cho, B; Kim, Y; Yang, YH; Min, KH; Cho, DH
- Issue Date
- Dec-2001
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- IL-18; skin tumors; squamous cell carcinoma
- Citation
- IMMUNOLOGY LETTERS, v.79, no.3, pp 215 - 219
- Pages
- 5
- Journal Title
- IMMUNOLOGY LETTERS
- Volume
- 79
- Number
- 3
- Start Page
- 215
- End Page
- 219
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16626
- DOI
- 10.1016/S0165-2478(01)00278-4
- ISSN
- 0165-2478
1879-0542
- Abstract
- Interleukin-18 (IL-18) has been found to have multiple effects upon various cells involved in inflammatory response. Recently we reported that B16 murine melanoma cells are able to produce IL-18, which is involved in the regulation of intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, indicating that IL-18 plays key role in the tumor activity of melanoma. In this study, we investigated the pattern of IL-18 expression in the human system. IL-18 production was tested by enzyme linked immunosorbent assay (ELISA) assay in various tumor cell lines, including Raji (Burkett's lymphoma), IM-9 (B lymphoblast), Jurkat (acute T cell leukemia), SK-MES-1 (squamous cell carcinoma (SCC) cell line), SK-MEL-2, G-361, DM-4, and DX-3 (melanoma cell lines). ELISA tests showed that IL-18 was highly expressed in malignant skin tumors such as SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 production may be associated with the malignancy of skin tumors. Here, we report that enhanced IL-18 expression is positively correlated with malignant skin tumors such as SCC and melanoma, suggesting the importance role of IL-18 in malignancy of skin tumors. Taken together, expression of IL-18 by tumor cells in human skin tissue may provide an important clue to understand the pathogenesis of malignant skin tumors. (C) 2001 Elsevier Science B.V. All rights reserved.
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