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Identification of metabolites of phytosterols in rat feces using GC/MS

Authors
Song, YSJin, CPark, EH
Issue Date
Dec-2000
Publisher
PHARMACEUTICAL SOCIETY KOREA
Keywords
phytosterols; beta-sitosterol; metabolites; rat feces; rat microsomes; GC/MS
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.23, no.6, pp.599 - 604
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
23
Number
6
Start Page
599
End Page
604
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16723
DOI
10.1007/BF02975248
ISSN
0253-6269
Abstract
beta -sitosterol, campesterol and stigmasterol have been known to the phytosterols the most frequently found in plants. Metabolism of phytosterols was investigated using rat feces and liver microsomes. Feces were collected after phytosterols (a well characterized mixture of beta -sitosterol 40%, campesterol 30% and dihydrobrasicasterol) were administered orally (0.5 g/kg) to rats. Metabolites of phytosterols were identified using GUMS. Three peaks were eluted at 12.47, 12.65, 12.87 min and had characteristic molecular ions m/z 428, 430, 432, respectively. Three fecal metabolites were identified as androstadienedione, androstenedione, and androstanedione. No metabolites could be detected in the rat liver microsomal reaction mixture. The results suggest that the metabolites of phytosterols in rat feces are formed by oxidation at 3- position, saturation at 5- and 6- position, and 17- side chain cleavage in the rat large intestine.
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