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Design and synthesis of new DNA photocleavers, 4 '-bromoacetophenone-pyrrolecarboxamide hybrid compounds

Authors
Jeon, RWender, PA
Issue Date
Dec-2000
Publisher
PHARMACEUTICAL SOCIETY KOREA
Keywords
4-bromoacetophenone; DNA cleaving agents; phenyl radical
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.23, no.6, pp.585 - 588
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
23
Number
6
Start Page
585
End Page
588
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16725
DOI
10.1007/BF02975245
ISSN
0253-6269
Abstract
4-Bromoacctophenone-pyrrolecarboxamide conjugates were designed and synthesized as photoinducible DNA cleaving agents which can generate monophenyl radicals capable of causing the hydrogen atom abstraction which initiates the scission of DNA.
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