Detailed Information

Cited 0 time in webofscience Cited 59 time in scopus
Metadata Downloads

Brain uptake and the analgesic effect of oxytocin - its usefulness as an analgesic agent

Full metadata record
DC Field Value Language
dc.contributor.authorKang, YS-
dc.contributor.authorPark, JH-
dc.date.available2021-02-22T16:47:02Z-
dc.date.issued2000-08-
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16746-
dc.description.abstractTo establish the usefulness of oxytocin (OT) as an analgesic for women in delivery, the pharmacokinetic parameters and blood-brain barrier (BBB) permeability of [H-3]OT were obtained using an intravenous injection technique or the internal carotid artery perfusion/capillary depletion (ICAP/CDM) method. Brain uptake of OT was similar to that of sucrose, plasma space marker, indicating that OT has a poor BBB permeability. Moreover, the analgesic effects of OT injected through the jugular vein on nociception were evaluated by the tail-flick method. The antinociceptive effects of OT injected at a dose of 0.2 mg/kg or 2 mg/kg were dose-dependent. In addition, the analgesic effects of OT on the CNS were unaffected by naloxone, a m-receptor antagonist. In a similar manner to the opioid system, OT may play a modulatory role in antinociception.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherPHARMACEUTICAL SOCIETY KOREA-
dc.titleBrain uptake and the analgesic effect of oxytocin - its usefulness as an analgesic agent-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.1007/BF02975453-
dc.identifier.scopusid2-s2.0-0034251879-
dc.identifier.wosid000088971900019-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.23, no.4, pp 391 - 395-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume23-
dc.citation.number4-
dc.citation.startPage391-
dc.citation.endPage395-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusCENTRAL-NERVOUS-SYSTEM-
dc.subject.keywordPlusBETA-ENDORPHIN-
dc.subject.keywordPlusBARRIER-
dc.subject.keywordPlusPEPTIDES-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusRATS-
dc.subject.keywordPlusTOLERANCE-
dc.subject.keywordPlusTRANSPORT-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordAuthoroxytocin-
dc.subject.keywordAuthorbrain uptake-
dc.subject.keywordAuthoranalgesic effect-
dc.subject.keywordAuthornaloxone-
Files in This Item
There are no files associated with this item.
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE