Detailed Information

Cited 0 time in webofscience Cited 4 time in scopus
Metadata Downloads

Designs and syntheses of oxathiin carboxanilide analogues and their antiviral activities

Full metadata record
DC FieldValueLanguage
dc.contributor.authorHahn, HC-
dc.contributor.authorRhee, HK-
dc.contributor.authorLee, CK-
dc.contributor.authorWhang, KJ-
dc.date.available2021-02-22T16:47:03Z-
dc.date.created2020-09-01-
dc.date.issued2000-08-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16748-
dc.description.abstractSyntheses of new analogues of oxathiin carboxanilide (UC84) and their antiviral activities were described. The heterocyclic carboxylic acids including oxathiins (4), thiazines (9) and dithiins (13) in which the methyl was replaced either by lipophilic trifluoromethyl- or bulky phenyl-group were synthesized starting from beta-keto esters (5). Reaction of 4, 9 and 13 with thionyl chloride followed by treatment of the substituted aniline 22 gave the corresponding carboxanilides (24a similar to 24f). The carboxanilides were subjected to Laweson's reagent the corresponding thiocarboxanilides (24g similar to 24k). The antiviral activities of the synthesized compounds against human immunodeficiency virus type 1 (HIV-1), poliovirus type 1 (PV-1), coxsackie B virus type 3 (CoxB-3), vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1) were presented. The antiviral activity against HIV-1 of dithiin carboxanilide (24e) was similar with that of UC84 (24a). The corresponding thiocarboxanilides (24g similar to 24k) showed higher inhibitory activity against HIV-1 than the carboxanilides (24a, 24b, 24d, 24e). The compounds in which ether the lipophilic trifluoromethyl substituents (24d, 24f, 24i, 24k) or bulky phenyl substituent is present in the heterocyclic compounds showed lower inhibitory activity than that of the methyl substituents is present in the compounds against the HIV-1. But the trifluoromethylated dithiin (24f) showed higher inhibitory activity against PV-1 and CoxB-3 virus than commercial antiviral agents, ribavirin (RV).-
dc.language영어-
dc.language.isoen-
dc.publisherPHARMACEUTICAL SOCIETY KOREA-
dc.subjectREVERSE-TRANSCRIPTASE INHIBITORS-
dc.subjectDERIVATIVES-
dc.subjectINVITRO-
dc.subjectREARRANGEMENT-
dc.subjectINFECTIVITY-
dc.subjectMECHANISMS-
dc.subjectPOTENT-
dc.subjectNNRTIS-
dc.titleDesigns and syntheses of oxathiin carboxanilide analogues and their antiviral activities-
dc.typeArticle-
dc.contributor.affiliatedAuthorWhang, KJ-
dc.identifier.doi10.1007/BF02975440-
dc.identifier.scopusid2-s2.0-0034251912-
dc.identifier.wosid000088971900006-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.23, no.4, pp.315 - 323-
dc.relation.isPartOfARCHIVES OF PHARMACAL RESEARCH-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume23-
dc.citation.number4-
dc.citation.startPage315-
dc.citation.endPage323-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusREVERSE-TRANSCRIPTASE INHIBITORS-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusINVITRO-
dc.subject.keywordPlusREARRANGEMENT-
dc.subject.keywordPlusINFECTIVITY-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusNNRTIS-
dc.subject.keywordAuthorheterocyclic carboxanilide-
dc.subject.keywordAuthoroxathiins-
dc.subject.keywordAuthorthiazines-
dc.subject.keywordAuthordithiins-
dc.subject.keywordAuthorthiocarboxanilides-
dc.subject.keywordAuthorantiviral activities-
Files in This Item
There are no files associated with this item.
Appears in
Collections
ETC > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE