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Polyacetylenes from Angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages

Authors
Choi, YEAhn, HRyu, JH
Issue Date
Jul-2000
Publisher
PHARMACEUTICAL SOC JAPAN
Keywords
Angelica gigas; polyacetylene; nitric oxide synthase; induction; LPS; inhibitor
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.23, no.7, pp.884 - 886
Journal Title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume
23
Number
7
Start Page
884
End Page
886
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/16755
ISSN
0918-6158
Abstract
In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of the toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. Two polyacetylenes were isolated from the medicinal plant Angelica gigas and their structures were elucidated as octadeca-1,9-dien-4,6-diyn-3,8,18-triol (1) and 18-acetoxy-octadeca-1,9-dien-4,6-diyn-3,8-diol (2) by spectroscopic method, These polyacetylenes and their peracetate, 3, 8, 18-triacetoxy-octadeca-1,9-dien-4,6-diyn (3) inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing the i-NOS enzyme expression. These new inhibitors of i-NOS expression may have potential in the treatment of endotoxemia and inflammation accompanied by the overproduction of NO.
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