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인삼사포닌에 의한 대식세포 일산화질소 생성 유도A Ginseng Saponin Induces Production of Nitric Oxide in Macrophages

Other Titles
A Ginseng Saponin Induces Production of Nitric Oxide in Macrophages
Authors
김지연이화진김지선안한나류재하
Issue Date
Feb-2005
Publisher
대한약학회
Keywords
nitric oxide; heat processing; ginseng; saponin
Citation
약 학 회 지, v.49, no.1, pp 80 - 85
Pages
6
Journal Title
약 학 회 지
Volume
49
Number
1
Start Page
80
End Page
85
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/17417
ISSN
0377-9556
Abstract
Ginseng root is an important remedy in oriental countries, which has been used for thousands of years. Saponins of ginseng root has been known to be the major component which mediate diverse pharmacological actions of the ginseng. Heat processing of ginseng root potentiates its biological activity such as anti-tumor and anti-oxidative activities. The butanol fraction of heat-processed ginseng (HGB) induced the production of nitric oxide in macrophages in a dose-dependent manner with IFN-g (30 U/ml) priming. The active component was identified as ginsenoside-Rg5 from the activity-guided purification. Ginsenoside Rg5 is one of major components of heat-processed ginseng and red ginseng that is responsible for the potentiated biological activities of processed ginseng. The induction of NO production by heat-processed ginseng might contribute to the potentiated biological activity of heat-processed ginseng.
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