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Synthesis and antiviral activity of D- and L-2 '-azido-2 ',3 '-dideoxy-4 '-thiopyrimidine and purine nucleosides
- Issue Date
- Apr-2001
- Publisher
- MARCEL DEKKER INC
- Citation
- NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.20, no.4-7, pp 665 - 668
- Pages
- 4
- Journal Title
- NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Volume
- 20
- Number
- 4-7
- Start Page
- 665
- End Page
- 668
- ISSN
- 1525-7770
- Abstract
- Novel D- and L-2'-azido-2',3'-dideoxy-4'-thionucleosides were synthesized starting from L- and D-xylose via D- and L-4-thioarabitol derivative as key intermediates and evaluated for antiviral activity, respectively. When the final nucleosides were tested against HIV-1, HSV-1, HSV-2, and HCMV, they were found to be only active against HCMV without cytotoxicity up to 100 mug/ml.
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