Detailed Information

Cited 0 time in webofscience Cited 4 time in scopus
Metadata Downloads

Structure-activity relationships of APIO nucleosides as potential antiviral agents

Authors
Jeong, LSMoon, HRHong, JHYoo, SJChoi, WJKim, HOAhn, HSBaek, HWChun, MWKim, HDKim, JChoi, JR
Issue Date
Apr-2001
Publisher
MARCEL DEKKER INC
Citation
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.20, no.4-7, pp 657 - 660
Pages
4
Journal Title
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume
20
Number
4-7
Start Page
657
End Page
660
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/17438
DOI
10.1081/NCN-100002344
ISSN
1525-7770
Abstract
Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.
Files in This Item
Go to Link
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE