Detailed Information

Cited 0 time in webofscience Cited 32 time in scopus
Metadata Downloads

Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk

Authors
연지영서영진김상욱백현욱성청자김현숙성미경승정자
Issue Date
Sep-2011
Publisher
JOURNAL OF NUTRITION
Citation
JOURNAL OF NUTRITION, v.27, no. 9, pp.912 - 918
Journal Title
JOURNAL OF NUTRITION
Volume
27
Number
9
Start Page
912
End Page
918
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/17530
DOI
10.1016/j.nut.2010.10.012
ISSN
0022-3166
Abstract
Objective: This study was conducted to evaluate blood concentrations of inflammatory cytokines and oxidative stress-related biomarkers as risk factors of breast cancer and to determine the relation between these markers and antioxidant nutrient intake. Methods: Study subjects were 134 patients with breast cancer and 149 controls. Total antioxidant capacity and concentrations of 8-isoprostane, 8-hydroxy-2′-deoxyguanosine, interleukin (IL)-1β, IL-6, and IL-8 of blood samples were determined. A food-frequency questionnaire was used to assess nutrient intake. Results: Patients with breast cancer had significantly higher blood levels of oxidative stress markers compared with control subjects. Plasma concentrations of IL-1β and IL-6 were significantly higher in patients with breast cancer compared with those of control subjects. In the pooled analysis, total antioxidant capacity was significantly decreased with increasing quartiles of carbohydrate intake but was increased with increasing quartiles of total vitamin A intake and vitamin C intake. In addition, 8-hydroxy-2′-deoxyguanosine concentration was decreased with increasing quartiles of vitamin A and β-carotene. No significant association was found between nutrient intake and cytokine concentrations. Conclusions: These results suggest that oxidative stress and inflammation may be associated with the risk of breast cancer. Total vitamin A intake was negatively related to oxidative stresses, possibly modifying the risk of breast cancer.
Files in This Item
Go to Link
Appears in
Collections
생활과학대학 > 식품영양학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Hyun Sook photo

Kim, Hyun Sook
생활과학대학 (식품영양학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE