Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Jae-ha | - |
dc.contributor.author | Lee, Hwa-jin | - |
dc.contributor.author | Jeong, Yeon-su | - |
dc.contributor.author | Ryu, Shiyong Young | - |
dc.contributor.author | Han, Yongnam | - |
dc.date.available | 2021-03-15T02:40:36Z | - |
dc.date.created | 2020-09-23 | - |
dc.date.issued | 1998-08 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/17537 | - |
dc.description.abstract | In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plant Artemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한약학회 | - |
dc.title | Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ryu, Jae-ha | - |
dc.identifier.doi | 10.1007/BF02974648 | - |
dc.identifier.scopusid | 2-s2.0-0032130376 | - |
dc.identifier.bibliographicCitation | Arch. Pharm. Res., v.21, no.4, pp. 481 - 484 | - |
dc.citation.title | Arch. Pharm. Res. | - |
dc.citation.volume | 21 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 481 | - |
dc.citation.endPage | 484 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2FBF02974648 | - |
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