Yomogin, an inhibitor of nitric oxide production in LPS-activated macrophages
- Authors
- Ryu, Jae-ha; Lee, Hwa-jin; Jeong, Yeon-su; Ryu, Shiyong Young; Han, Yongnam
- Issue Date
- Aug-1998
- Publisher
- 대한약학회
- Citation
- Archives of Pharmacal Research, v.21, no.4, pp 481 - 484
- Journal Title
- Archives of Pharmacal Research
- Volume
- 21
- Number
- 4
- Start Page
- 481
- End Page
- 484
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/17538
- DOI
- 10.1007/BF02974648
- ISSN
- 0253-6269
1976-3786
- Abstract
- In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (yomogin) isolated from medicinal plant Artemisia princeps Pampan inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing i-NOS enzyme expression. Thus, yomogin may be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.
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