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새로운 항암성 제리쿠드라닌 E 유도체의 합성 및 항암활성Synthesis and Antitumour Activity of Novel Gericudranin E Derivatives
- Other Titles
- Synthesis and Antitumour Activity of Novel Gericudranin E Derivatives
- Issue Date
- Oct-1999
- Publisher
- 대한약학회
- Citation
- 약 학 회 지, v.43, no.5, pp.559 - 565
- Journal Title
- 약 학 회 지
- Volume
- 43
- Number
- 5
- Start Page
- 559
- End Page
- 565
- ISSN
- 0377-9556
- Abstract
- The two gericudranin E derivatives, GER-I & II, were synthesized and evaluated their anti-tumour activities for the elucidation of structure-activity relationship. 2,4,6-Trihydroxyacetophenone was converted to target molecules GER-I and GER-B in 5 steps via sequential protection, aldol condensation, Michael type-cyclization, regioselective C-benzylation. The cellular growth inhibition of compounds GER-I and GER-II were investigated against P388, L1210, K562, HCT-15, SK-HepG-1, MCF-7 as cancer cell lines and mouse splenocytes as a normal cell by MTT assay.
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