Ginsenoside Rg1 from Panax ginseng enhances myoblast differentiation and myotube growthopen access
- Authors
- Go, Ga-Yeon; Lee, Sang-Jin; Jo, Ayoung; Lee, Jaecheol; Seo, Dong-Wan; Kang, Jong-Sun; Kim, Si-Kwan; Kim, Su-Nam; Kim, Yong Kee; Bae, Gyu-Un
- Issue Date
- Oct-2017
- Publisher
- KOREAN SOC GINSENG
- Keywords
- ginsenoside Rg1; myoblast differentiation; myogenic conversion; myotube hypertrophy; promyogenic signaling
- Citation
- JOURNAL OF GINSENG RESEARCH, v.41, no.4, pp 608 - 614
- Pages
- 7
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- Volume
- 41
- Number
- 4
- Start Page
- 608
- End Page
- 614
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2235
- DOI
- 10.1016/j.jgr.2017.05.006
- ISSN
- 1226-8453
2093-4947
- Abstract
- Background: Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth. Methods: C2C12 myoblasts, MyoD-transfected 10T1/2 embryonic fibroblasts, and HEK293T cells were treated with Rg1 and differentiated for 2 d, subjected to immunoblotting, immunocytochemistry, or immunoprecipitation. Results: Rg1 activated promyogenic kinases, p38MAPK (mitogen-activated protein kinase) and Akt signaling, that in turn promote the heterodimerization with MyoD and E proteins, resulting in enhancing myogenic differentiation. Through the activation of Akt/mammalian target of rapamycin pathway, Rg1 induced myotube growth and prevented dexamethasone-induced myotube atrophy. Furthermore, Rg1 increased MyoD-dependent myogenic conversion of fibroblast. Conclusion: Rg1 upregulates promyogenic kinases, especially Akt, resulting in improvement of myoblast differentiation and myotube growth. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
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