Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

The Role of Erythroid Differentiation Regulator 1 (ERDR1) in the Control of Proliferation and Photodynamic Therapy (PDT) Responseopen access

Authors
Park, SunyoungKim, Kyung EunPark, Hyun JeongCho, Daeho
Issue Date
Apr-2020
Publisher
MDPI
Keywords
erythroid differentiation regulator 1 (ERDR1); photodynamic therapy (PDT); skin cancer; skin disease; apoptosis
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.21, no.7
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
21
Number
7
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2475
DOI
10.3390/ijms21072603
ISSN
1661-6596
Abstract
Erythroid differentiation regulator 1 (ERDR1) was newly identified as a secreted protein that plays an essential role in maintaining cell growth homeostasis. ERDR1 enhances apoptosis at high cell densities, leading to the inhibition of cell survival. Exogenous ERDR1 treatment decreases cancer cell proliferation and tumor growth as a result of increased apoptosis via the regulation of apoptosis-related gene expression. Moreover, ERDR1 plays a pivotal role in skin diseases; ERDR1 expression in actinic keratosis (AK) is negatively correlated with the increase in apoptosis. Because of its high specificity and efficiency, photodynamic therapy (PDT) is a common therapy for patients with various skin diseases, including cancer. Many studies indicate that apoptosis is mainly induced by PDT treatment. As an apoptosis inducer, the recovery of the ERDR1 expression after PDT is correlated with good therapeutic outcomes. Here, we review recent findings that highlight the function of ERDR1 in the control of apoptosis. Thus, ERDR1 may have a role in the apoptosis regulation of target cells in the lesions, as the recovery of its expression after PDT is correlated with good therapeutic outcomes.
Files in This Item
Go to Link
Appears in
Collections
원격대학원 > 향장미용학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Kyung Eun photo

Kim, Kyung Eun
원격대학원 (향장미용학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE