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Z-Ajoene Inhibits Growth of Colon Cancer by Promotion of CK1 alpha Dependent beta-Catenin Phosphorylation

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dc.contributor.authorLi, Hua-
dc.contributor.authorJeong, Ji Hye-
dc.contributor.authorKwon, Sung Won-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorLee, Hwa Jin-
dc.contributor.authorRyu, Jae-Ha-
dc.date.available2021-02-22T05:35:42Z-
dc.date.issued2020-02-
dc.identifier.issn1420-3049-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2527-
dc.description.abstractAberrant activation of a Wnt/beta-catenin pathway results in nuclear accumulation of beta-catenin in colon cancer. Inhibiting beta-catenin is one strategy for treating colon cancer. Here, we identified Z-ajoene, a sulfur containing compound isolated from crushed garlic, as an inhibitor of colon cancer cell growth. Z-Ajoene repressed beta-catenin response transcriptional activity, intracellular beta-catenin levels, and its representative target protein levels (c-Myc and cyclin D1) in SW480 colon cancer cells. To clarify the regulatory mechanism of decreased beta-catenin levels, we examined the effect of Z-ajoene on beta-catenin phosphorylation, which is involved in beta-catenin degradation. Z-Ajoene promoted the phosphorylation of beta-catenin at Ser45 in a casein kinase 1 alpha (CK1 alpha)-dependent manner, which is an essential step in beta-catenin degradation in the cytosol. These findings indicate that Z-ajoene from garlic may be a potential chemotherapeutic agent by modulating CK1 alpha activity and the Wnt/beta-catenin signaling pathway.-
dc.language영어-
dc.language.isoENG-
dc.publisherMDPI-
dc.titleZ-Ajoene Inhibits Growth of Colon Cancer by Promotion of CK1 alpha Dependent beta-Catenin Phosphorylation-
dc.typeArticle-
dc.publisher.location스위스-
dc.identifier.doi10.3390/molecules25030703-
dc.identifier.scopusid2-s2.0-85079212107-
dc.identifier.wosid000515384800273-
dc.identifier.bibliographicCitationMOLECULES, v.25, no.3-
dc.citation.titleMOLECULES-
dc.citation.volume25-
dc.citation.number3-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusGARLIC BY-PRODUCT-
dc.subject.keywordPlusWNT-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusCELLS-
dc.subject.keywordAuthorcolon cancer-
dc.subject.keywordAuthorbeta-catenin-
dc.subject.keywordAuthorZ-ajoene-
dc.subject.keywordAuthorphosphorylation-
dc.subject.keywordAuthorcasein kinase 1 alpha-
dc.identifier.urlhttps://www.mdpi.com/1420-3049/25/3/703-
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