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Revolutionizing technologies of nanomicelles for combinatorial anticancer drug delivery

Authors
Jo, Min JeongJin, Ik SupPark, Chun-WoongHwang, Bang YeonChung, Youn BokKim, Jin-SeokShin, Dae Hwan
Issue Date
Jan-2020
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
Nanotechnology; Drug combination; Micelles; Anticancer drugs; Solubilization
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.43, no.1, pp 100 - 109
Pages
10
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
43
Number
1
Start Page
100
End Page
109
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2569
DOI
10.1007/s12272-020-01215-4
ISSN
0253-6269
1976-3786
Abstract
Insufficient efficacy of current single drug therapy of cancers have led to the advancement of combination drug-loaded formulations. Specifically, polymeric micelles have been focused on as efficient injectable vehicles for the delivery of several anticancer drugs simultaneously to cancer cells. These nano delivery systems have evolved with advancements in the area of nanotechnology. The current review presents a summary of the past events that have led to the procession of nanomicelles and novel nanotechnologies for combinatorial drug delivery. It also focuses on the advantages, disadvantages, and considerations for the design of nanotechnologies for combinatorial drug delivery systems. The opportunities and challenges of nanotechnologies in drug delivery to overcome current disadvantages are also discussed. Furthermore, we have added findings regarding the trends and perspectives regarding nanotechnologies for combinatorial anticancer drug delivery.
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