Detailed Information

Cited 0 time in webofscience Cited 3 time in scopus
Metadata Downloads

Bridged alpha-helix mimetic small molecules

Authors
Lee, YeongjuIm, HaeriDas, SanketOh, MisookLee, Ji HoonHam, SihyunLim, Hyun-Suk
Issue Date
Nov-2019
Publisher
ROYAL SOC CHEMISTRY
Citation
CHEMICAL COMMUNICATIONS, v.55, no.88, pp 13311 - 13314
Pages
4
Journal Title
CHEMICAL COMMUNICATIONS
Volume
55
Number
88
Start Page
13311
End Page
13314
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2747
DOI
10.1039/c9cc03627j
ISSN
1359-7345
1364-548X
Abstract
Herein, we report a strategy for generating conformationally restricted alpha-helix mimetic small molecules by introducing covalent bridges that limit rotation about the central axis of alpha-helix mimetics. We demonstrate that the bridged alpha-helix mimetics have enhanced binding affinity and specificity to the target protein due to the restricted conformation as well as extra interaction of the bridge with the protein surface.
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 화학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE