Detailed Information

Cited 0 time in webofscience Cited 2 time in scopus
Metadata Downloads

Ginsenoside Rg1 augments oxidative metabolism and anabolic response of skeletal muscle in miceopen access

Authors
Jeong, Hyeon-JuSo, Hyun-KyungJo, AyoungKim, Hye-BeenLee, Sang-JinBae, Gyu-UnKang, Jong-Sun
Issue Date
Jul-2019
Publisher
KOREAN SOC GINSENG
Keywords
Atrophy; Exercise-specific signaling; Ginsenoside; Rg1; Skeletal muscle
Citation
JOURNAL OF GINSENG RESEARCH, v.43, no.3, pp 475 - 481
Pages
7
Journal Title
JOURNAL OF GINSENG RESEARCH
Volume
43
Number
3
Start Page
475
End Page
481
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/2943
DOI
10.1016/j.jgr.2018.04.005
ISSN
1226-8453
2093-4947
Abstract
Background: The ginsenoside Rg1 has been shown to exert various pharmacological activities with health benefits. Previously, we have reported that Rg1 promoted myogenic differentiation and myotube growth in C2C12 myoblasts. In this study, the in vivo effect of Rg1 on fiber-type composition and oxidative metabolism in skeletal muscle was examined. Methods: To examine the effect of Rg1 on skeletal muscle, 3-month-old mice were treated with Rg1 for 5 weeks. To assess muscle strength, grip strength tests were performed, and the lower hind limb muscles were harvested, followed by various detailed analysis, such as histological staining, immunoblotting, immunostaining, and real-time quantitative reverse transcription polymerase chain reaction. In addition, to verify the in vivo data, primary myoblasts isolated from mice were treated with Rg1, and the Rg1 effect on myotube growth was examined by immunoblotting and immunostaining analysis. Results: Rg1 treatment increased the expression of myosin heavy chain isoforms characteristic for both oxidative and glycolytic muscle fibers; increased myofiber sizes were accompanied by enhanced muscle strength. Rg1 treatment also enhanced oxidative muscle metabolism with elevated oxidative phosphorylation proteins. Furthermore, Rg1-treated muscles exhibited increased levels of anabolic S6 kinase signaling. Conclusion: Rg1 improves muscle functionality via enhancing muscle gene expression and oxidative muscle metabolism in mice. (C) 2018 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
Files in This Item
Go to Link
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Bae, Gyu Un photo

Bae, Gyu Un
약학대학 (약학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE